Altered expression of E-cadherin in breast cancer. patterns, mechanisms and clinical significance.

doi:10.1016/s0959-8049(00)00062-9

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Article

Altered expression of E-cadherin in breast cancer. patterns, mechanisms and clinical significance.

European journal of cancer (Oxford, England : 1990) - 1 Jun 2000

Asgeirsson K S, Jónasson J G, Tryggvadóttir L, Olafsdóttir K, Sigurgeirsdóttir J R, Ingvarsson S, Ogmundsdóttir H M

Abstract excerpt

Reduced cell adhesion brought about by altered surface expression of E-cadherin has been implicated in invasive and metastatic malignant growth. We investigated the patterns of immunohistochemical E-cadherin expression in 120 breast carcinomas. Furthermore, we analysed DNA from the same samples for loss of heterozygosity (LOH) using three separate microsatellite markers on chromosome 16q22.1. Finally, the...

Topics

Adult
Aged
Aged, 80 and over
Breast Neoplasms
Cadherins
DNA, Neoplasm
Disease-Free Survival
Female
Humans
Immunohistochemistry
Loss of Heterozygosity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microsatellite Repeats

Middle Aged

Mutation

Neoplasm Metastasis

Neoplasm Proteins

Neoplasm Recurrence, Local

Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 10854942
DOI: 10.1016/s0959-8049(00)00062-9

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