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Article

Relation between p53 overexpression and established prognostic factors in breast cancer.

Surgery - 1 Aug 1991

Davidoff A M, Herndon J E, Glover N S, Kerns B J, Pence J C, Iglehart J D, Marks J R

Abstract excerpt

The nuclear phosphoprotein p53 is expressed in all normal cells and appears to function in cell cycle regulation. Abnormally high levels of the protein are found in many different types of cancer. In breast carcinoma overexpression of p53 is associated with point mutations within highly conserved regions of the p53 gene. These altered genes encode stable p53 proteins that can be detected by standard...

Topics

Breast Neoplasms
Carcinoma
Female
Gene Expression Regulation, Neoplastic
Genes, p53
Humans
Immunohistochemistry
Mutation
Neoplasm Staging
Prognosis
Tumor Suppressor Protein p53

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Identifiers

PMID: 1858036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1858036-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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