Article
Polyclonal structure of intestinal adenomas in ApcMin/+ mice with concomitant loss of Apc+ from all tumor lineages.
Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 1997
Merritt A J, Gould K A, Dove W F
Abstract excerpt
When tumors form in intestinal epithelia, it is important to know whether they involve single initiated somatic clones. Advanced carcinomas in humans and mice are known to be monoclonal. However, earlier stages of tumorigenesis may instead involve an interaction between cells that belong to separ...
Topics
- Adenomatous Polyposis Coli
- Adenomatous Polyposis Coli Protein
- Animals
- Chimera
- Clone Cells
- Cytoskeletal Proteins
- Female
- Genes, APC
- Genotype
- Humans
- Immunohistochemistry
- Loss of Heterozygosity
- Male
- Mice
- Mice, Mutant Strains
- Models, Genetic
- Mosaicism