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Article

Polyclonal structure of intestinal adenomas in ApcMin/+ mice with concomitant loss of Apc+ from all tumor lineages.

Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 1997

Merritt A J, Gould K A, Dove W F

Abstract excerpt

When tumors form in intestinal epithelia, it is important to know whether they involve single initiated somatic clones. Advanced carcinomas in humans and mice are known to be monoclonal. However, earlier stages of tumorigenesis may instead involve an interaction between cells that belong to separate somatic clones within the epithelium. The clonality of early tumors has been investigated in mice with an inherited...

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Identifiers

PMID: 9391129
DOI: 10.1073/pnas.94.25.13927
PMCID: PMC28409

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Polyclonal structure of intestinal adenomas in ApcMin/+ mice with concomitant loss of Apc+ from all tumor lineages.PMID 9391129Read ↗

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Intestinal adenomas can develop with a stable karyotype and stable microsatellitesSemantic proximity Read ↗

Polyclonality overcomes fitness barriers in Apc-driven tumorigenesis.Semantic proximity Read ↗

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Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas.Semantic proximity Read ↗

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