Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Different phenotypic consequences of simultaneous versus stepwise Apc loss.

Oncogene - 19 Apr 2012

Fischer J M, Miller A J, Shibata D, Liskay R M

Abstract excerpt

APC is considered a gatekeeper for colorectal cancer (CRC). Cells with heterozygous APC mutations have altered expression profiles suggesting that the first APC hit may help set the stage for subsequent transformation. Therefore, we measured transformation efficiency following what we have designated as 'simultaneous' versus 'stepwise' Apc loss. We combined a conditional Apc allele (Apc(CKO)) with a Cre reporter...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Cell Transformation, Neoplastic
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, APC

Share to Integrases

Share to Intestine, Small

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 21892206
DOI: 10.1038/onc.2011.385
PMCID: PMC3235266

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Different phenotypic consequences of simultaneous versus stepwise Apc loss.PMID 21892206Read ↗

Decay of driver mutations shapes the landscape of intestinal transformation.Semantic proximity Read ↗

Chir99021 and Valproic acid reduce the proliferative advantage of Apc mutant cells.Semantic proximity Read ↗

Occult progression by Apc-deficient intestinal crypts as a target for chemoprevention.Semantic proximity Read ↗

Early mutational events and clonal dynamics in normal crypts: implications for colorectal tumorigenesis.Semantic proximity Read ↗

Polyclonality overcomes fitness barriers in Apc-driven tumorigenesis.Semantic proximity Read ↗

Sox9 Induction, Ectopic Paneth Cells, and Mitotic Spindle Axis Defects in Mouse Colon Adenomatous Epithelium Arising From Conditional Biallelic Apc InactivationSemantic proximity Read ↗

Polyclonal structure of intestinal adenomas in ApcMin/+ mice with concomitant loss of Apc+ from all tumor lineages.Semantic proximity Read ↗

APC and the three-hit hypothesis.Semantic proximity Read ↗

E-cadherin can limit the transforming properties of activating β-catenin mutations.Semantic proximity Read ↗

Complete deletion of Apc results in severe polyposis in mice.Semantic proximity Read ↗

The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression.Semantic proximity Read ↗

E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.