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Article

Intestinal adenomas can develop with a stable karyotype and stable microsatellites

11 Jun 2002

Abstract excerpt

Loss of function of the adenomatous polyposis coli (APC)/Apc tumor suppressor gene occurs early in the etiology of intestinal cancer in mammals. In human colonic tumors, genomic instability is proposed to be associated with tumor initiation by inducing loss of APC function. We have used a mouse model of inherited intestinal cancer (Apc(Min)/+, Min/+) to analyze the earliest stages of tumorigenesis in this organ....

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Identifiers

PMID: 12060718
DOI: 10.1073/pnas.132275099

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Intestinal adenomas can develop with a stable karyotype and stable microsatellitesPMID 12060718Read ↗

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