Article
Polyclonality of familial murine adenomas: analyses of mouse chimeras with low tumor multiplicity suggest short-range interactions.
Proceedings of the National Academy of Sciences of the United States of America - 10 May 2005
Thliveris Andrew T, Halberg Richard B, Clipson Linda, Dove William F, Sullivan Ruth, Washington Mary Kay, Stanhope Stephen, Newton Michael A
Abstract excerpt
In previous studies demonstrating the polyclonal structure of familial intestinal adenomas, high tumor multiplicity made it difficult to eliminate the possibility that polyclonality arose by the random collision of distinct initiated clones as opposed to some form of clonal interaction. We sought to test further the random collision hypothesis. Chimeric mice carrying the multiple intestinal neoplasia (Min)...
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