Article
A resistant genetic background leading to incomplete penetrance of intestinal neoplasia and reduced loss of heterozygosity in ApcMin/+ mice.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1998
Shoemaker A R, Moser A R, Midgley C A, Clipson L, Newton M A, Dove W F
Abstract excerpt
Previous studies of Min/+ (multiple intestinal neoplasia) mice on a sensitive genetic background, C57BL/6 (B6), showed that adenomas have lost heterozygosity for the germ-line ApcMin mutation in the Apc (adenomatous polyposis coli) gene. We now report that on a strongly resistant genetic backgrou...
Topics
- Adenoma
- Alleles
- Animals
- Carcinogens
- Ethylnitrosourea
- Genes, APC
- Germ-Line Mutation
- Intestinal Neoplasms
- Loss of Heterozygosity
- Mice