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Article

A resistant genetic background leading to incomplete penetrance of intestinal neoplasia and reduced loss of heterozygosity in ApcMin/+ mice.

Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1998

Shoemaker A R, Moser A R, Midgley C A, Clipson L, Newton M A, Dove W F

Abstract excerpt

Previous studies of Min/+ (multiple intestinal neoplasia) mice on a sensitive genetic background, C57BL/6 (B6), showed that adenomas have lost heterozygosity for the germ-line ApcMin mutation in the Apc (adenomatous polyposis coli) gene. We now report that on a strongly resistant genetic background, AKR/J (AKR), Min-induced adenoma multiplicity is reduced by about two orders of magnitude compared with that...

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Identifiers

PMID: 9724789
DOI: 10.1073/pnas.95.18.10826
PMCID: PMC27980

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A resistant genetic background leading to incomplete penetrance of intestinal neoplasia and reduced loss of heterozygosity in ApcMin/+ mice.PMID 9724789Read ↗

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