Article
Clonal structure of carcinogen-induced intestinal tumors in mice.
Cancer prevention research (Philadelphia, Pa.) - 1 Jun 2011
Thliveris Andrew T, Clipson Linda, White Alanna, Waggoner Jesse, Plesh Lauren, Skinner Bridget L, Zahm Christopher D, Sullivan Ruth, Dove William F, Newton Michael A, Halberg Richard B
Abstract excerpt
Previous studies have shown that intestinal tumors from Apc(Min)(/+) (Min) mice and familial adenomatous polyposis (FAP) patients are often polyclonal. We sought to determine whether polyclonality is unique to tumors arising from hereditary predispositions or, instead, is a common feature of intestinal tumorigenesis in other pathways to tumorigenesis. Ethylnitrosourea-induced intestinal tumors from mice wild type...
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