Article
The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system.
The Journal of cell biology - 1 Mar 1992
Moser A R, Dove W F, Roth K A, Gordon J I
Abstract excerpt
Min is a fully penetrant dominant mutation that leads to the development of multiple intestinal adenomas throughout the duodenal-to-colonic axis. Min/+ C57BL6/J mice have an average life-span of 120 d. Multi-label immunocytochemical studies of these lesions demonstrate patches of differentiated e...
Topics
- Adenoma
- Animals
- Carrier Proteins
- Cell Differentiation
- Crosses, Genetic
- Epithelium
- Fatty Acid-Binding Protein 7
- Fatty Acid-Binding Proteins
- Fatty Acids
- Intestinal Mucosa
- Intestinal Neoplasms
- Mice
- Mice, Inbred Strains
- Mice, Mutant Strains
- Mucins
- Muramidase
- Mutation
- Neoplasm Proteins