Article
Emergent issues in the genetics of intestinal neoplasia.
Cancer surveys - 1 Jan 1995
Dove W F, Gould K A, Luongo C, Moser A R, Shoemaker A R
Abstract excerpt
Mutation of the APC gene may be a common denominator of all human colon cancer--polypoid and non-polypoid familial cancer as well as sporadic occurrences. Fearon and Vogelstein (1990) have described a series of molecular changes during the progression of human colon cancer, beginning with mutatio...
Topics
- Adenomatous Polyposis Coli
- Alleles
- Animals
- Colorectal Neoplasms
- Genes, APC
- Genes, p53
- Heterozygote
- Homozygote
- Humans
- Intestinal Neoplasms
- Mice
- Neoplasms, Experimental
- Phenotype