Article
Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas.
Gastroenterology - 1 Apr 2010
Thirlwell Christina, Will Olivia C C, Domingo E, Graham Trevor A, McDonald Stuart A C, Oukrif Dahmane, Jeffrey Rosemary, Gorman Maggie, Rodriguez-Justo Manuel, Chin-Aleong Joanne, Clark Sue K, Novelli Marco R, Jankowski Janusz A, Wright Nicholas A, Tomlinson Ian P M, Leedham Simon J
Abstract excerpt
BACKGROUND & AIMS: According to the somatic mutation theory, monoclonal colorectal lesions arise from sequential mutations in the progeny of a single stem cell. However, studies in a sex chromosome mixoploid mosaic (XO/XY) patient indicated that colorectal adenomas were polyclonal. We assessed adenoma clonality on an individual crypt basis and completed a genetic dependency analysis in carcinomas-in-adenomas to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.