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Article

Polyclonality overcomes fitness barriers in Apc-driven tumorigenesis.

Nature - 1 Oct 2024

Sadien Iannish D, Adler Sam, Mehmed Shenay, Bailey Sasha, Sawle Ashley, Couturier Dominique-Laurent, Eldridge Matthew, Adams David J, Kemp Richard, Lourenço Filipe C, Winton Douglas J

Abstract excerpt

Loss-of-function mutations in the tumour suppressor APC are an initial step in intestinal tumorigenesis1,2. APC-mutant intestinal stem cells outcompete their wild-type neighbours through the secretion of Wnt antagonists, which accelerates the fixation and subsequent rapid clonal expansion of mutants3-5. Reports of polyclonal intestinal tumours in human patients and mouse models appear at odds with this...

Topics

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Adenomatous Polyposis Coli Protein
Clone Cells
Genes, APC
Genetic Fitness
Intestinal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Loss of Function Mutation

Neoplastic Stem Cells

Proto-Oncogene Proteins c-myc

Source

Open in PubMed Open full text

Identifiers

PMID: 39478206
DOI: 10.1038/s41586-024-08053-0
PMCID: PMC11525183

Genes

APC
KRAS
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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