Article
Sodium channel activation gating is affected by substitutions of voltage sensor positive charges in all four domains.
The Journal of general physiology - 1 Oct 1997
Kontis K J, Rounaghi A, Goldin A L
Abstract excerpt
The role of the voltage sensor positive charges in the activation and deactivation gating of the rat brain IIA sodium channel was investigated by mutating the second and fourth conserved positive charges in the S4 segments of all four homologous domains. Both charge-neutralizing (by glutamine sub...
Topics
- Amino Acid Sequence
- Animals
- Brain Chemistry
- Conserved Sequence
- Electrophysiology
- Ion Channel Gating
- Kinetics
- Membrane Potentials
- Molecular Sequence Data
- Mutation
- Oocytes
- Patch-Clamp Techniques
- Rats
- Sodium Channels
- Xenopus laevis