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Article

Role of hydrophobic residues in the voltage sensors of the voltage-gated sodium channel.

Biochimica et biophysica acta - 1 Jun 2007

Bendahhou Saïd, O'Reilly Andrias O, Duclohier Hervé

Abstract excerpt

The role of hydrophobic residues in voltage sensors S4 of voltage-sensitive ion channels is less documented than that of charged residues. We performed alanine-substitution of branched-sidechain residues contiguous to the third, fourth and fifth positively charged residues in S4s of the first three domains of the sodium channel expressed in HEK cells. These locations were selected because they are close to the...

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Identifiers

PMID: 17442264
DOI: 10.1016/j.bbamem.2007.03.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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