Article
Ion permeation through a voltage- sensitive gating pore in brain sodium channels having voltage sensor mutations.
Neuron - 21 Jul 2005
Sokolov Stanislav, Scheuer Todd, Catterall William A
Abstract excerpt
Voltage-gated sodium channels activate in response to depolarization, but it is unknown whether the voltage-sensing arginines in their S4 segments pivot across the lipid bilayer as voltage sensor paddles or move through the protein in a gating pore. Here we report that mutation of pairs of arginine gating charges to glutamine induces cation permeation through a gating pore in domain II of the Na(V)1.2a channel....
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