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Article

Upward movement of IS4 and IIIS4 is a rate-limiting stage in Cav1.2 activation.

Pflugers Archiv : European journal of physiology - 1 Nov 2016

Beyl Stanislav, Hohaus Annette, Andranovits Stanislav, Timin Eugen, Hering Steffen

Abstract excerpt

In order to specify the role of individual S4 segments in CaV1.2 gating, charged residues of segments IS4-IVS4 were replaced by glutamine and the corresponding effects on activation/deactivation of calcium channel currents were analysed. Almost all replacements of charges in IS4 and IIIS4 decreased the slope of the Boltzmann curve of channel activation (activation curve) while charge neutralisations in IIS4 and...

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Identifiers

PMID: 27796578
DOI: 10.1007/s00424-016-1895-5
PMCID: PMC5138263

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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