Article

Broadband Tuning the Voltage Dependence of a Sodium Channel

2020-11-21

Abstract excerpt

<h4>ABSTRACT</h4> Voltage-gated sodium channels initiate action potentials in prokaryotes and in many eukaryotic cells, including vertebrate nerve and muscle. Their activation is steeply voltage-dependent, but it is unclear how the voltage sensitivity is set or whether it can be broadly shifted to positive voltages. Here we show that the voltage dependence of activation (V A ) of the ancestral bacterial sodium c...

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Literature Corpus work: 824d3ab6-95af-5943-aa3f-b6eeec93ae79
DOI: 10.1101/2020.11.21.392571

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