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Article

Outer and central charged residues in DIVS4 of skeletal muscle sodium channels have differing roles in deactivation.

Biophysical journal - 1 Mar 2002

Groome James, Fujimoto Esther, Walter Lisa, Ruben Peter

Abstract excerpt

We tested the effects of charge-neutralizing mutations of the eight arginine residues in DIVS4 of the rat skeletal muscle sodium channel (rNa(V)1.4) on deactivation gating from the open and inactivated states. We hypothesized that neutralization of outer or central charges would accelerate the I-to-C transition as measured by recovery delay because these represent a portion of the immobilizable charge. R1Q...

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Identifiers

PMID: 11867446
DOI: 10.1016/S0006-3495(02)75485-4
PMCID: PMC1301932

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Source receipt: pubmed, retrieved 7 Sept 2026.

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