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Article

Sodium channel inactivation is altered by substitution of voltage sensor positive charges.

The Journal of general physiology - 1 Oct 1997

Kontis K J, Goldin A L

Abstract excerpt

The role of the voltage sensor positive charges in fast and slow inactivation of the rat brain IIA sodium channel was investigated by mutating the second and fourth conserved positive charges in the S4 segments of all four homologous domains. Both charge-neutralizing mutations (by glutamine substitution) and charge-conserving mutations were constructed in a cDNA encoding the sodium channel alpha subunit. To...

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Identifiers

PMID: 9379172
DOI: 10.1085/jgp.110.4.403
PMCID: PMC2229380

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Source receipt: pubmed, retrieved 7 Sept 2026.

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