Article
Sodium channel inactivation is altered by substitution of voltage sensor positive charges.
The Journal of general physiology - 1 Oct 1997
Kontis K J, Goldin A L
Abstract excerpt
The role of the voltage sensor positive charges in fast and slow inactivation of the rat brain IIA sodium channel was investigated by mutating the second and fourth conserved positive charges in the S4 segments of all four homologous domains. Both charge-neutralizing mutations (by glutamine subst...
Topics
- Amino Acid Sequence
- Animals
- Brain Chemistry
- Electrophysiology
- Ion Channel Gating
- Kinetics
- Membrane Potentials
- Molecular Sequence Data
- Mutation
- Oocytes
- Patch-Clamp Techniques
- Rats
- Sodium Channel Blockers
- Sodium Channels
- Xenopus laevis