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Article

Neutralisation of a single voltage sensor affects gating determinants in all four pore-forming S6 segments of Ca(V)1.2: a cooperative gating model.

Pflugers Archiv : European journal of physiology - 1 Oct 2012

Beyl Stanislav, Depil Katrin, Hohaus Annette, Stary-Weinzinger Anna, Linder Tobias, Timin Eugen, Hering Steffen

Abstract excerpt

Voltage sensors trigger the closed-open transitions in the pore of voltage-gated ion channels. To probe the transmission of voltage sensor signalling to the channel pore of Ca(V)1.2, we investigated how elimination of positive charges in the S4 segments (charged residues were replaced by neutral glutamine) modulates gating perturbations induced by mutations in pore-lining S6 segments. Neutralisation of all...

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Identifiers

PMID: 22941337
DOI: 10.1007/s00424-012-1144-5
PMCID: PMC3790253

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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