Article
Domain IV voltage-sensor movement is both sufficient and rate limiting for fast inactivation in sodium channels.
The Journal of general physiology - 1 Aug 2013
Capes Deborah L, Goldschen-Ohm Marcel P, Arcisio-Miranda Manoel, Bezanilla Francisco, Chanda Baron
Abstract excerpt
Voltage-gated sodium channels are critical for the generation and propagation of electrical signals in most excitable cells. Activation of Na(+) channels initiates an action potential, and fast inactivation facilitates repolarization of the membrane by the outward K(+) current. Fast inactivation is also the main determinant of the refractory period between successive electrical impulses. Although the voltage...
Topics
- Action Potentials
- Amino Acid Sequence
- Animals
- Ion Channel Gating
- Membrane Potentials
- Molecular Sequence Data
- Mutation
- Protein Structure, Tertiary
- Rats
- Voltage-Gated Sodium Channels