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Article

A unique role for the S4 segment of domain 4 in the inactivation of sodium channels.

The Journal of general physiology - 1 Dec 1996

Chen L Q, Santarelli V, Horn R, Kallen R G

Abstract excerpt

Sodium channels have four homologous domains (D1-D4) each with six putative transmembrane segments (S1-S6). The highly charged S4 segments in each domain are postulated voltage sensors for gating. We made 15 charge-neutralizing or -reversing substitutions in the first or third basic residues (arginine or lysine) by replacement with histidine, glutamine, or glutamate in S4 segments of each domain of the human...

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Identifiers

PMID: 8972392
DOI: 10.1085/jgp.108.6.549
PMCID: PMC2229343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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