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Article

Negative charges in the DIII-DIV linker of human skeletal muscle Na+ channels regulate deactivation gating.

The Journal of physiology - 1 Apr 2003

Groome James R, Fujimoto Esther, Ruben Peter C

Abstract excerpt

Charge reversing, neutralizing and substituting mutations at D1309 and EE1314,15 in the DIII-DIV linker of the human skeletal muscle sodium channel hNav1.4 were constructed and expressed in Xenopus oocytes. The effects of these mutations on conductance, inactivation and deactivation were determined using on-cell macropatches. D1309R caused a depolarizing shift of the conductance-voltage (g(V)) curve and increased...

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Identifiers

PMID: 12588896
DOI: 10.1113/jphysiol.2002.033084
PMCID: PMC2342797

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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