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Article

Constitutive activation of gene expression by thyroid hormone receptor results from reversal of p53-mediated repression.

Molecular and cellular biology - 1 Dec 1997

Qi J S, Desai-Yajnik V, Yuan Y, Samuels H H

Abstract excerpt

Thyroid hormone receptor (T3R) is a member of the steroid hormone receptor gene family of nuclear hormone receptors. In most cells T3R activates gene expression only in the presence of its ligand, L-triiodothyronine (T3). However, in certain cell types (e.g., GH4C1 cells) expression of T3R leads to hormone-independent constitutive activation. This activation by unliganded T3R occurs with a variety of gene...

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Identifiers

PMID: 9372952
DOI: 10.1128/MCB.17.12.7195
PMCID: PMC232577

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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