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Article

Thyroid hormone receptors mutated in liver cancer function as distorted antimorphs.

Oncogene - 15 Jun 2006

Chan I H, Privalsky M L

Abstract excerpt

Aberrant thyroid hormone receptors (TRs) are found in over 70% of the human hepatocellular carcinomas (HCCs) analysed. To better understand the role(s) of these TR mutants in this neoplasia, we analysed a panel of HCC mutant receptors for their molecular properties. Virtually all HCC-associated TR mutants tested retained the ability to repress target genes in the absence of T3, yet were impaired in T3-driven gene...

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Share to Carcinoma, Hepatocellular
Share to Electrophoretic Mobility Shift Assay
Share to Liver Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptors, Thyroid Hormone

Share to Repressor Proteins

Share to Transcriptional Activation

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Share to Triiodothyronine

Source

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Identifiers

PMID: 16434963
DOI: 10.1038/sj.onc.1209389
PMCID: PMC2701908

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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