Nuclear corepressors enhance the dominant negative activity of mutant receptors that cause resistance to thyroid hormone.

doi:10.1210/endo.139.2.5742

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Article

Nuclear corepressors enhance the dominant negative activity of mutant receptors that cause resistance to thyroid hormone.

Endocrinology - 1 Feb 1998

Tagami T, Jameson J L

Abstract excerpt

The syndrome of resistance to thyroid hormone (RTH) is caused by multiple distinct mutations in the ligand-binding domain of the thyroid hormone receptor-beta (TRbeta). Although the mutant receptors are transcriptionally inactive, they inhibit normal receptor function in a dominant negative manne...

Topics

Amino Acid Sequence
Drug Resistance
Gene Expression Regulation
Genes, Dominant
Humans
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
Nuclear Proteins
Receptors, Thyroid Hormone
Repressor Proteins
Thyroid Hormones

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