Identification of a growth hormone gene promoter repressor element and its cognate double- and single-stranded DNA-binding proteins.

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Article

Identification of a growth hormone gene promoter repressor element and its cognate double- and single-stranded DNA-binding proteins.

The Journal of biological chemistry - 25 Apr 1990

Pan W T, Liu Q R, Bancroft C

Abstract excerpt

In previous investigations, cell fusion was found to silence either the endogenous rat growth hormone (GH) gene or a transfected rat GH gene promoter, implying that repression plays a role in regulation of this gene. To search the rat GH gene promoter for repressor sequences, a series of 5'-deleted GH-CAT constructs was analyzed by transient expression in GH3 rat pituitary cells. Deletion of either a distal...

Topics

Animals
Base Sequence
Binding Sites
Cell Line
Chromosome Deletion
DNA-Binding Proteins
Genes
Growth Hormone
Humans
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligonucleotide Probes

Promoter Regions, Genetic

Rats

Repressor Proteins

Transcription Factors

Transfection

Source

Open in PubMed

Identifiers

PMID: 2324110

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2324110-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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