Article
Identification of a growth hormone gene promoter repressor element and its cognate double- and single-stranded DNA-binding proteins.
The Journal of biological chemistry - 25 Apr 1990
Pan W T, Liu Q R, Bancroft C
Abstract excerpt
In previous investigations, cell fusion was found to silence either the endogenous rat growth hormone (GH) gene or a transfected rat GH gene promoter, implying that repression plays a role in regulation of this gene. To search the rat GH gene promoter for repressor sequences, a series of 5'-deleted GH-CAT constructs was analyzed by transient expression in GH3 rat pituitary cells. Deletion of either a distal...
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