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Article

Negative and positive transcriptional regulation by thyroid hormone receptor isoforms.

Molecular endocrinology (Baltimore, Md.) - 1 Oct 1990

Rentoumis A, Chatterjee V K, Madison L D, Datta S, Gallagher G D, Degroot L J, Jameson J L

Abstract excerpt

Multiple forms of human thyroid hormone (T3) receptor have been identified, including true receptors that bind T3 (alpha 1 and beta) and a splicing variant (alpha 2) that does not bind T3. The alpha 1- and beta-receptors activate transcription through interactions with positive thyroid response elements (TREs). The alpha 2 variant is unable to activate transcription and has been reported to inhibit alpha 1 or...

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PMID: 2284000
DOI: 10.1210/mend-4-10-1522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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