Article
Negative and positive transcriptional regulation by thyroid hormone receptor isoforms.
Molecular endocrinology (Baltimore, Md.) - 1 Oct 1990
Rentoumis A, Chatterjee V K, Madison L D, Datta S, Gallagher G D, Degroot L J, Jameson J L
Abstract excerpt
Multiple forms of human thyroid hormone (T3) receptor have been identified, including true receptors that bind T3 (alpha 1 and beta) and a splicing variant (alpha 2) that does not bind T3. The alpha 1- and beta-receptors activate transcription through interactions with positive thyroid response e...
Topics
- Binding Sites
- Chloramphenicol O-Acetyltransferase
- DNA
- Gene Expression Regulation
- Genetic Variation
- Humans
- Plasmids
- RNA Splicing
- Receptors, Thyroid Hormone
- Thyrotropin
- Transcription, Genetic
- Transfection
- Triiodothyronine