Article
Wild-type but not mutant p53 can repress transcription initiation in vitro by interfering with the binding of basal transcription factors to the TATA motif.
Oncogene - 1 May 1993
Ragimov N, Krauskopf A, Navot N, Rotter V, Oren M, Aloni Y
Abstract excerpt
It has previously been shown that excess wild type (wt) p53 can repress the transcriptional activity of a variety of promoters in intact cells. To determine whether this transcriptional repression represented a direct effect of p53, wt and mutant p53 were prepared from E. coli-produced p53 and fr...
Topics
- Base Sequence
- Cell Line, Transformed
- DNA-Binding Proteins
- Genes, myc
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- RNA, Messenger
- TATA Box
- TATA-Box Binding Protein
- Transcription Factor TFIIA
- Transcription Factors
- Transcription, Genetic
- Tumor Suppressor Protein p53