Article
Mutations in the conserved C-terminal sequence in thyroid hormone receptor dissociate hormone-dependent activation from interference with AP-1 activity.
Molecular and cellular biology - 1 Aug 1997
Saatcioglu F, Lopez G, West B L, Zandi E, Feng W, Lu H, Esmaili A, Apriletti J W, Kushner P J, Baxter J D, Karin M
Abstract excerpt
A short C-terminal sequence that is deleted in the v-ErbA oncoprotein and conserved in members of the nuclear receptor superfamily is required for normal biological function of its normal cellular counterpart, the thyroid hormone receptor alpha (T3R alpha). We carried out an extensive mutational analysis of this region based on the crystal structure of the hormone-bound ligand binding domain of T3R alpha....
Topics
- Amino Acid Sequence
- Animals
- COS Cells
- Conserved Sequence
- DNA-Binding Proteins
- HeLa Cells
- Humans
- Ligands
- Models, Molecular
- Mutation
- Nuclear Receptor Coactivator 2