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Article

Binding of the thyroid hormone receptor to a negative element in the basal growth hormone promoter is associated with histone acetylation.

The Journal of biological chemistry - 10 Oct 2003

Sánchez-Pacheco Aurora, Aranda Ana

Abstract excerpt

Nuclear thyroid hormone receptors (TRs) act as ligand-dependent activators, but paradoxically unliganded TRs can increase transcription of promoters containing negative response elements (nTRE), and hormone binding represses this activation. The rat growth hormone (GH) promoter contains a positive TRE and a nTRE. Ligand-dependent negative regulation mediated by the nTRE could play an important physiological role...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12878587
DOI: 10.1074/jbc.M306988200

Genes

HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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