Article
The nuclear receptor corepressor deacetylase activating domain is essential for repression by thyroid hormone receptor.
Molecular endocrinology (Baltimore, Md.) - 1 Jun 2005
Ishizuka Takahiro, Lazar Mitchell A
Abstract excerpt
Nuclear receptor corepressor (N-CoR) mediates repression by thyroid hormone receptor (TR) as well as other nuclear hormone receptors and transcription factors. N-CoR contains several repression domains that repress transcription when fused to a heterologous DNA binding domain, but their relative importance in the full-length N-CoR molecule is unknown. Here we addressed this important issue by depleting N-CoR in...
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