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Article

Thyroid Hormone Negatively Regulates the Transcriptional Activity of the β-Amyloid Precursor Protein Gene

1 Nov 1998

Abstract excerpt

The expression of the beta-amyloid precursor protein (APP), which plays a key role in the development of Alzheimer's disease, is regulated by a variety of cellular mediators in a cell-dependent manner. In the present study, we present evidence that thyroid hormones negatively regulate the expression of the APP gene in neuroblastoma cells. Transient transfection studies using plasmids that contain progressive...

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PMID: 9804800
DOI: 10.1074/jbc.273.46.30366

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Related research

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Thyroid Hormone Negatively Regulates the Transcriptional Activity of the β-Amyloid Precursor Protein GenePMID 9804800Read ↗

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Thyroid Hormones Regulate β-Amyloid Gene Splicing and Protein Secretion in Neuroblastoma Cells<sup>1</sup>Semantic proximity Read ↗

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Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP.Semantic proximity Read ↗

Binding of the thyroid hormone receptor to a negative element in the basal growth hormone promoter is associated with histone acetylation.Semantic proximity Read ↗

Sp1 and Smad transcription factors co-operate to mediate TGF-beta-dependent activation of amyloid-beta precursor protein gene transcription.Semantic proximity Read ↗

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Oct-1, silencer sequence, and GC box regulate thyroid hormone receptor beta1 promoter.Semantic proximity Read ↗

Characterization of the <i>APP</i> proximal promoter and 5′‐untranslated regions: identification of cell‐type specific domains and implications in <i>APP</i> gene expression and Alzheimer's diseaseSemantic proximity Read ↗

A response element for the homeodomain transcription factor Ptx3 in the tyrosine hydroxylase gene promoter.Semantic proximity Read ↗

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