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Article

Hormone-dependent and -independent transcriptional activation by thyroid hormone receptors are mediated by different mechanisms.

Endocrinology - 1 Feb 1996

Helmer E B, Raaka B M, Samuels H H

Abstract excerpt

Transcriptional activation by thyroid hormone (T3) receptor (T3R) generally requires the binding of its high affinity ligand. However, we reported previously that chicken T3R alpha (cTaR alpha) and human T3R beta 1 (hT3R beta 1) could activate transcription from several promoters containing T3R response elements (TREs) in a hormone-independent fashion when expressed in rat anterior pituitary GH4C1 cells. In this...

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PMID: 8593781
DOI: 10.1210/endo.137.2.8593781

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