Article
Studies on the repression of basal transcription (silencing) by artificial and natural human thyroid hormone receptor-beta mutants.
Endocrinology - 1 Jul 1995
Yen P M, Wilcox E C, Hayashi Y, Refetoff S, Chin W W
Abstract excerpt
Thyroid hormone receptors (TRs) are ligand-dependent transcription factors that regulate target gene transcription. Interestingly, in the absence of ligand, TRs also can repress basal transcription of positively regulated target genes, suggesting that unliganded TR may have a distinct role in gene regulation. In this paper, DNA binding, truncation, and natural human TR beta mutants were used in cotransfection and...
Topics
- Base Sequence
- Binding Sites
- DNA
- Humans
- Macromolecular Substances
- Mutagenesis
- Mutation
- Receptors, Thyroid Hormone
- Repressor Proteins
- Transcription, Genetic
- Transfection