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Identification of a third autonomous activation domain within the human estrogen receptor.

Molecular endocrinology (Baltimore, Md.) - 1 Jun 1997

Norris J D, Fan D, Kerner S A, McDonnell D P

Abstract excerpt

Using a genetic selection system established in the yeast Saccharomyces cerevisiae, we have isolated, by random mutagenesis of the human estrogen receptor (ER), six mutants that display constitutive transcriptional activity. All of the mutants identified contained single base insertions or deletions leading to frameshift mutations, resulting in receptor truncations within the hormone-binding domain between amino...

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PMID: 9171238
DOI: 10.1210/mend.11.6.0008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification of a third autonomous activation domain within the human estrogen receptor.PMID 9171238Read ↗

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