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Article

A highly efficient and sensitive screening method for trans-activation activity of estrogen receptors.

Gene - 13 Mar 2003

Chen Zhilei, Zhao Huimin

Abstract excerpt

We describe a highly efficient and sensitive yeast-based screening method for isolating human estrogen receptor alpha (ERalpha) mutants with altered trans-activation activity. This method takes advantage of the fact that estrogen receptor is a ligand-activated transcription factor, and links the transactivation activity of estrogen receptor to the growth rate of yeast cells. We used this method to screen a...

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Identifiers

PMID: 12657474
DOI: 10.1016/s0378-1119(03)00431-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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