Estrogenic activity is increased for an antiestrogen by a natural mutation of the estrogen receptor.

doi:10.1016/s0960-0760(96)00184-7

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Article

Estrogenic activity is increased for an antiestrogen by a natural mutation of the estrogen receptor.

The Journal of steroid biochemistry and molecular biology - 1 Mar 1997

Levenson A S, Catherino W H, Jordan V C

Abstract excerpt

The estrogen receptor (ER) functions as a ligand-activated transcription factor which mediates the actions of estrogens and antiestrogens in target tissues. Other investigators have shown that artificial point mutations in the transcriptional activation domain AF-2 of the ligand binding domain (L...

Topics

Breast Neoplasms
Cell Division
Dose-Response Relationship, Drug
Estradiol
Estrogen Antagonists
Female
Fulvestrant
Gene Expression Regulation, Neoplastic
Humans
Mutation
Piperidines
RNA, Messenger

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Neoplasm

Raloxifene Hydrochloride

Receptors, Estrogen

Transfection

Transforming Growth Factor alpha

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 9219916
DOI: 10.1016/s0960-0760(96)00184-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9219916-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Estrogenic activity is increased for an antiestrogen by a natural mutation of the estrogen receptor.PMID 9219916Read ↗

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The Estrogen Receptor -Isoform (ER ) of the Human Estrogen Receptor Modulates ER Transcriptional Activity and Is a Key Regulator of the Cellular Response to Estrogens and AntiestrogensSemantic proximity Read ↗

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