Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Estrogenic activity is increased for an antiestrogen by a natural mutation of the estrogen receptor.

The Journal of steroid biochemistry and molecular biology - 1 Mar 1997

Levenson A S, Catherino W H, Jordan V C

Abstract excerpt

The estrogen receptor (ER) functions as a ligand-activated transcription factor which mediates the actions of estrogens and antiestrogens in target tissues. Other investigators have shown that artificial point mutations in the transcriptional activation domain AF-2 of the ligand binding domain (LBD) of the ER can increase the estrogenic properties of antiestrogens, determined by transcriptional activation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Tumor Cells, Cultured
Share to Breast Neoplasms
Share to Cell Division

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Drug

Share to Gene Expression Regulation, Neoplastic

Share to Mutation

Share to RNA, Messenger

Share to Transfection

Source

Identifiers

PMID: 9219916
DOI: 10.1016/s0960-0760(96)00184-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Estrogenic activity is increased for an antiestrogen by a natural mutation of the estrogen receptor.PMID 9219916Read ↗

Ligand-independent activation of the estrogen receptors alpha and beta by mutations of a conserved tyrosine can be abolished by antiestrogens.Semantic proximity Read ↗

The biological action of cDNAs from mutated estrogen receptors transfected into breast cancer cells.Semantic proximity Read ↗

The estrogen receptor from a tamoxifen stimulated MCF-7 tumor variant contains a point mutation in the ligand binding domain.Semantic proximity Read ↗

Estrogen receptor mutations in human disease.Semantic proximity Read ↗

Antiestrogens activate an estrogen receptor mutant exhibiting enhanced binding to the estrogen response element.Semantic proximity Read ↗

An analysis of tamoxifen-stimulated human carcinomas for mutations in the AF-2 region of the estrogen receptor.Semantic proximity Read ↗

Differential activation of wild-type estrogen receptor alpha and C-terminal deletion mutants by estrogens, antiestrogens and xenoestrogens in breast cancer cells.Semantic proximity Read ↗

Different Regions in Activation Function-1 of the Human Estrogen Receptor Required for Antiestrogen- and Estradiol-dependent Transcription ActivationSemantic proximity Read ↗

Inhibition of estrogen receptor action by a naturally occurring variant in human breast tumors.Semantic proximity Read ↗

The Estrogen Receptor -Isoform (ER ) of the Human Estrogen Receptor Modulates ER Transcriptional Activity and Is a Key Regulator of the Cellular Response to Estrogens and AntiestrogensSemantic proximity Read ↗

Identification of a third autonomous activation domain within the human estrogen receptor.Semantic proximity Read ↗

Neutral mutations to three acidic AF2 residues in the mouse estrogen receptor confer agonist activity to A-ring isomers of estradiol.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.