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Article

Generation of estrogen receptor mutants with altered ligand specificity for use in establishing a regulatable gene expression system.

The Journal of steroid biochemistry and molecular biology - 1 Apr 1996

Whelan J, Miller N

Abstract excerpt

Considerable interest exists in developing an artificial system for the control of gene expression, based on the hormone binding domain (HBD) of steroid receptors. In this study we describe a yeast based approach which allows the identification of mutations within the HBD of steroid receptors, in this case the estrogen receptor, which result in altered specificity of the HBD with respect to its activation by...

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Source

Identifiers

PMID: 8809181
DOI: 10.1016/0960-0760(96)00010-6

Genes

HBD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Generation of estrogen receptor mutants with altered ligand specificity for use in establishing a regulatable gene expression system.PMID 8809181Read ↗

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