Structure-function analysis of the hormone binding domain of the human estrogen receptor by region-specific mutagenesis and phenotypic screening in yeast.

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Article

Structure-function analysis of the hormone binding domain of the human estrogen receptor by region-specific mutagenesis and phenotypic screening in yeast.

The Journal of biological chemistry - 15 Nov 1993

Wrenn C K, Katzenellenbogen B S

Abstract excerpt

To investigate the structural requirements for recognition and response to ligands by the human estrogen receptor (hER), a series of point mutations were generated in the hormone binding domain (HBD) of the receptor using a limited formic acid treatment of its cDNA. Receptors having a reduced sen...

Topics

Animals
CHO Cells
Cricetinae
Estradiol
Humans
Mutagenesis, Site-Directed
Phenotype
Receptors, Estrogen
Saccharomyces cerevisiae
Structure-Activity Relationship
Tamoxifen
Transcriptional Activation

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Open in PubMed

Identifiers

PMID: 8226955

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8226955-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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