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Article

Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex.

The EMBO journal - 17 Mar 1997

Kutay U, Izaurralde E, Bischoff F R, Mattaj I W, Görlich D

Abstract excerpt

Nuclear protein import proceeds through the nuclear pore complex (NPC). Importin-beta mediates translocation via direct interaction with NPC components and carries importin-alpha with the NLS substrate from the cytoplasm into the nucleus. The import reaction is terminated by the direct binding of nuclear RanGTP to importin-beta which dissociates the importin heterodimer. Here, we analyse the sites of interaction...

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Identifiers

PMID: 9135132
DOI: 10.1093/emboj/16.6.1153
PMCID: PMC1169714

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