Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.

The Journal of cell biology - 22 Aug 2011

Hamada Masakazu, Haeger Anna, Jeganathan Karthik B, van Ree Janine H, Malureanu Liviu, Wälde Sarah, Joseph Jomon, Kehlenbach Ralph H, van Deursen Jan M

Abstract excerpt

RanBP2/Nup358, the major component of the cytoplasmic filaments of the nuclear pore complex (NPC), is essential for mouse embryogenesis and is implicated in both macromolecular transport and mitosis, but its specific molecular functions are unknown. Using RanBP2 conditional knockout mouse embryonic fibroblasts and a series of mutant constructs, we show that transport, rather than mitotic, functions of RanBP2 are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Karyopherins
Share to Heterogeneous-Nuclear Ribonucleoprotein Group A-B

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Microscopy, Video

Share to Nuclear Localization Signals

Share to Nuclear Pore

Share to Nuclear Pore Complex Proteins

Share to ran GTP-Binding Protein

Share to Small Ubiquitin-Related Modifier Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 21859863
DOI: 10.1083/jcb.201102018
PMCID: PMC3160583

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.PMID 21859863Read ↗

The nucleoporin Nup50 activates the Ran guanine nucleotide exchange factor RCC1 to promote NPC assembly at the end of mitosis.Semantic proximity Read ↗

Early embryonic requirement for nucleoporin Nup35/NPP-19 in nuclear assembly.Semantic proximity Read ↗

The role of the ran GTPase in nuclear assembly and DNA replication: characterisation of the effects of Ran mutants.Semantic proximity Read ↗

Role of importin-beta in the control of nuclear envelope assembly by Ran.Semantic proximity Read ↗

Nup358, a Cytoplasmically Exposed Nucleoporin with Peptide Repeats, Ran-GTP Binding Sites, Zinc Fingers, a Cyclophilin A Homologous Domain, and a Leucine-rich RegionSemantic proximity Read ↗

Stimulation of nuclear export and inhibition of nuclear import by a Ran mutant deficient in binding to Ran-binding protein 1.Semantic proximity Read ↗

Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.Semantic proximity Read ↗

NEMF mutations in mice illustrate how Importin-β specific nuclear transport defects recapitulate neurodegenerative disease hallmarks.Semantic proximity Read ↗

Essential role of the small GTPase Ran in postnatal pancreatic islet development.Semantic proximity Read ↗

NNF1 is an essential yeast gene required for proper spindle orientation, nucleolar and nuclear envelope structure and mRNA export.Semantic proximity Read ↗

Crm1 is a mitotic effector of Ran-GTP in somatic cells.Semantic proximity Read ↗

Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.