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Article

Importin beta negatively regulates nuclear membrane fusion and nuclear pore complex assembly.

Molecular biology of the cell - 1 Nov 2003

Harel Amnon, Chan Rene C, Lachish-Zalait Aurelie, Zimmerman Ella, Elbaum Michael, Forbes Douglass J

Abstract excerpt

Assembly of a eukaryotic nucleus involves three distinct events: membrane recruitment, fusion to form a double nuclear membrane, and nuclear pore complex (NPC) assembly. We report that importin beta negatively regulates two of these events, membrane fusion and NPC assembly. When excess importin beta is added to a full Xenopus nuclear reconstitution reaction, vesicles are recruited to chromatin but their fusion is...

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Source

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Identifiers

PMID: 14551248
DOI: 10.1091/mbc.e03-05-0275
PMCID: PMC266759

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Importin beta negatively regulates nuclear membrane fusion and nuclear pore complex assembly.PMID 14551248Read ↗

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RanGTP mediates nuclear pore complex assembly.Semantic proximity Read ↗

GTP hydrolysis by Ran is required for nuclear envelope assembly.Semantic proximity Read ↗

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A dominant-negative form of POM121 binds chromatin and disrupts the two separate modes of nuclear pore assembly.Semantic proximity Read ↗

The nucleoporin Nup50 activates the Ran guanine nucleotide exchange factor RCC1 to promote NPC assembly at the end of mitosis.Semantic proximity Read ↗

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Structural basis for nuclear import complex dissociation by RanGTP.Semantic proximity Read ↗

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