Article
Role of importin-beta in the control of nuclear envelope assembly by Ran.
Current biology : CB - 19 Mar 2002
Zhang Chuanmao, Hutchins James R A, Mühlhäusser Petra, Kutay Ulrike, Clarke Paul R
Abstract excerpt
Compartmentalization of the genetic material into a nucleus bounded by a nuclear envelope (NE) is the hallmark of a eukaryotic cell. The control of NE assembly is poorly understood, but in a cell-free system made from Xenopus eggs, NE assembly involves the small GTPase Ran. In this system, Sepharose beads coated with Ran induce the formation of functional NEs in the absence of chromatin. Here, we show that...
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