Article
Interactions between HIV Rev and nuclear import and export factors: the Rev nuclear localisation signal mediates specific binding to human importin-beta.
Journal of molecular biology - 19 Dec 1997
Henderson B R, Percipalle P
Abstract excerpt
The human immunodeficiency virus type 1 (HIV-1) Rev protein binds to unspliced HIV-1 pre-mRNA and exports it from the nucleus. Rev itself can "shuttle" between the nucleus and cytoplasm. This bi-directional transport is mediated by two specific Rev sequences: a nuclear localisation signal (NLS),...
Topics
- Amino Acid Sequence
- Antibodies, Monoclonal
- Antibodies, Viral
- Biological Transport
- Cell Nucleus
- Epitopes
- Gene Products, rev
- Guanosine Triphosphate
- HIV-1
- HeLa Cells
- Humans
- Karyopherins
- Molecular Sequence Data
- Mutation
- Nuclear Localization Signals
- Nuclear Pore Complex Proteins
- Nuclear Proteins
- Peptide Initiation Factors