Article
A novel receptor-mediated nuclear protein import pathway.
Cell - 20 Sept 1996
Pollard V W, Michael W M, Nakielny S, Siomi M C, Wang F, Dreyfuss G
Abstract excerpt
Targeting of most nuclear proteins to the cell nucleus is initiated by interaction between the classical nuclear localization signals (NLSs) contained within them and the importin NLS receptor complex. We have recently delineated a novel 38 amino acid transport signal in the hnRNP A1 protein, termed M9, which confers bidirectional transport across the nuclear envelope. We show here that M9-mediated nuclear import...
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