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Article

A Ran-independent pathway for export of spliced mRNA.

Nature cell biology - 1 Jan 2001

Clouse K N, Luo M J, Zhou Z, Reed R

Abstract excerpt

All major nuclear export pathways so far examined follow a general paradigm. Specifically, a complex is formed in the nucleus, containing the export cargo, a member of the importin-beta family of transporters and RanGTP. This complex is translocated across the nuclear pore to the cytoplasm, where hydrolysis of the GTP on Ran is stimulated by the GTPase-activating protein RanGAP. The activity of RanGAP is...

Topics

Active Transport, Cell Nucleus
Animals
Cell Nucleus
GTPase-Activating Proteins
Kinetics
Mutation
Oocytes
RNA Splicing
RNA, Messenger
RNA, Small Nuclear
RNA, Transfer
Xenopus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Xenopus Proteins

ran GTP-Binding Protein

Source

Identifiers

PMID: 11146633
DOI: 10.1038/35050625

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A Ran-independent pathway for export of spliced mRNA.PMID 11146633Read ↗

Requirement of guanosine triphosphate-bound ran for signal-mediated nuclear protein export.Semantic proximity Read ↗

Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex.Semantic proximity Read ↗

RanGTP-binding protein NXT1 facilitates nuclear export of different classes of RNA in vitro.Semantic proximity Read ↗

TPR is required for the nuclear export of mRNAs and lncRNAs from intronless and intron-poor genesSemantic proximity Read ↗

Coordination of tRNA nuclear export with processing of tRNA.Semantic proximity Read ↗

Nuclear RanGTP is not required for targeting small nucleolar RNAs to the nucleolus.Semantic proximity Read ↗

Messenger RNAs are recruited for nuclear export during transcription.Semantic proximity Read ↗

Utp8p is a nucleolar tRNA-binding protein that forms a complex with components of the nuclear tRNA export machinery in Saccharomyces cerevisiae.Semantic proximity Read ↗

Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR.Semantic proximity Read ↗

A non-canonical mechanism for Crm1-export cargo complex assembly.Semantic proximity Read ↗

Rev-mediated nuclear export of RNA is dominant over nuclear retention and is coupled to the Ran-GTPase cycle.Semantic proximity Read ↗

Facilitated nucleocytoplasmic shuttling of the Ran binding protein RanBP1.Semantic proximity Read ↗

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