Article
A Ran-independent pathway for export of spliced mRNA.
Nature cell biology - 1 Jan 2001
Clouse K N, Luo M J, Zhou Z, Reed R
Abstract excerpt
All major nuclear export pathways so far examined follow a general paradigm. Specifically, a complex is formed in the nucleus, containing the export cargo, a member of the importin-beta family of transporters and RanGTP. This complex is translocated across the nuclear pore to the cytoplasm, where hydrolysis of the GTP on Ran is stimulated by the GTPase-activating protein RanGAP. The activity of RanGAP is...
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