Article
Molecular dissection of the importin beta1-recognized nuclear targeting signal of parathyroid hormone-related protein.
Biochemical and biophysical research communications - 30 Mar 2001
Lam M H, Hu W, Xiao C Y, Gillespie M T, Jans D A
Abstract excerpt
Produced by various types of solid tumors, parathyroid hormone-related protein (PTHrP) is the causative agent of humoral hypercalcemia of malignancy. The similarity of PTHrP's amino-terminus to that of parathyroid hormone enables it to share some of the latter's signalling properties, but its carboxy-terminus confers distinct functions including a role in the nucleus/nucleolus in reducing apoptosis and enhancing...
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