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Article

A non-canonical mechanism for Crm1-export cargo complex assembly.

eLife - 21 Apr 2015

Fischer Ute, Schäuble Nico, Schütz Sabina, Altvater Martin, Chang Yiming, Faza Marius Boulos, Panse Vikram Govind

Abstract excerpt

The transport receptor Crm1 mediates the export of diverse cargos containing leucine-rich nuclear export signals (NESs) through complex formation with RanGTP. To ensure efficient cargo release in the cytoplasm, NESs have evolved to display low affinity for Crm1. However, mechanisms that overcome low affinity to assemble Crm1-export complexes in the nucleus remain poorly understood. In this study, we reveal a new...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25895666
DOI: 10.7554/eLife.05745
PMCID: PMC4402694

Genes

NES

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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