TNF Nco-I RFLP is not an independent risk factor in rheumatoid arthritis.

doi:10.1111/j.1744-313x.1994.tb00219.x

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Article

TNF Nco-I RFLP is not an independent risk factor in rheumatoid arthritis.

European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Dec 1994

Campbell D A, Nelson S, Madhok R, Field M, Gallagher G

Abstract excerpt

The human TNF genes are located within the MHC class-III region on chromosome 6. The presence or absence of an Nco-I restriction site in the 5' non-coding sequence of the TNF beta gene defines two alleles (TNFB*1 and TNFB*2). The segregation of these alleles has been associated with levels of TNF...

Topics

Alleles
Arthritis, Rheumatoid
Base Sequence
DNA Primers
Deoxyribonucleases, Type II Site-Specific
Haplotypes
Humans
Polymorphism, Restriction Fragment Length
Risk Factors
Synovial Fluid
Tumor Necrosis Factor-alpha

Source

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Identifiers

PMID: 9098456
DOI: 10.1111/j.1744-313x.1994.tb00219.x

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9098456-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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