Article
TNF Nco-I RFLP is not an independent risk factor in rheumatoid arthritis.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Dec 1994
Campbell D A, Nelson S, Madhok R, Field M, Gallagher G
Abstract excerpt
The human TNF genes are located within the MHC class-III region on chromosome 6. The presence or absence of an Nco-I restriction site in the 5' non-coding sequence of the TNF beta gene defines two alleles (TNFB*1 and TNFB*2). The segregation of these alleles has been associated with levels of TNF alpha or TNF beta production in systemic lupus erythematosis (SLE), insulin-dependent diabetes mellitus (IDDM) and in...
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